Research Program

Inspired by small molecule natural products, the Roizen laboratories has initiated research with a long-term vision to access improved antibiotics, and selective ion channel inhibitors, with implications for the study and treatment of cancer, heart disease, and neurological disorders. This program has begun with the development of novel reaction methods, and where appropriate these methodologies will be advanced through mechanistic investigations. New reactions have been designed to streamline access to challenging natural products, such as the guaianolide sesquiterpenes. Access to these small molecules will enable us to collaborate with colleagues to probe the biological activity of these molecular architectures.